IGF-1 LR3
A long-acting IGF-1 analog studied as the downstream effector of growth-hormone signaling.
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IGF-1 LR3 (Long R3 IGF-1) is an 83–amino-acid analog of insulin-like growth factor 1, carrying an Arg³ substitution and a 13-residue N-terminal extension that reduce its binding to IGF-binding proteins and extend its activity. It is a core reference material in growth-factor and cell-proliferation research.
Mechanism & receptor biology
Research examines its activation of the IGF-1 receptor and downstream PI3K/Akt and MAPK signaling, and — because it largely evades IGFBP sequestration — its prolonged availability in cell- and tissue-culture systems.
Research context
Used in cell-proliferation, muscle-biology and tissue-growth research as a long-acting IGF-1 reference analog.
Reference specifications
| Sequence | 83-residue IGF-1 analog (Arg³, N-terminal extension) |
|---|---|
| Molecular formula | C₉₉₀H₁₅₃₂N₂₆₂O₃₀₁S₇ |
| Molecular weight | 9111 g/mol |
| CAS number | 946870-92-4 |
IGF-1 LR3 is offered strictly for laboratory and research use only. It is not a drug, supplement, or article of food, and is not intended to diagnose, treat, cure, or prevent any disease, nor for human or animal consumption. The information above is an educational summary of published receptor biology and does not constitute medical advice.
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