MOTS-c
A 16-residue mitochondrial-encoded “mitokine” studied as a metabolic exercise-mimetic.
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MOTS-c is a 16–amino-acid peptide encoded within the mitochondrial 12S rRNA gene — one of the first mitochondrial-derived peptides shown to act systemically as a “mitokine.” It is a major focus of metabolic-longevity research.
Mechanism & receptor biology
Research examines its activation of the AMPK energy-sensing pathway and its influence on glucose uptake and fatty-acid oxidation in skeletal-muscle models, effects often described as exercise-mimetic in the literature.
Research context
Used in metabolic and mitochondrial-aging research as a reference mitochondrial-derived peptide.
Reference specifications
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
|---|---|
| Molecular formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular weight | 2174.64 g/mol |
| CAS number | 1627580-64-6 |
MOTS-c is offered strictly for laboratory and research use only. It is not a drug, supplement, or article of food, and is not intended to diagnose, treat, cure, or prevent any disease, nor for human or animal consumption. The information above is an educational summary of published receptor biology and does not constitute medical advice.
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