Tirzepatide
The dual GIP/GLP-1 agonist that defined the twincretin research category.
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Tirzepatide is a 39–amino-acid synthetic peptide and the archetype of the “twincretin” class — a single molecule designed to engage two incretin receptors at once. It is among the most extensively characterized metabolic research peptides available.
Mechanism & receptor biology
It acts as a dual agonist at the GIP and GLP-1 receptors. Research focuses on how balanced co-activation of these two pathways affects insulinotropic signaling and downstream metabolic cascades relative to single-receptor GLP-1 agonists.
Research context
The compound is used in receptor-signaling and comparative-pharmacology research to benchmark dual- versus mono-agonist activity. Its long fatty-acid modification, which extends circulating half-life in models, is itself a subject of study.
Reference specifications
| Sequence | 39-residue acylated peptide |
|---|---|
| Molecular formula | C₂₂₅H₃₄₈N₄₈O₆₈ |
| Molecular weight | 4813.53 g/mol |
| CAS number | 2023788-19-2 |
Tirzepatide is offered strictly for laboratory and research use only. It is not a drug, supplement, or article of food, and is not intended to diagnose, treat, cure, or prevent any disease, nor for human or animal consumption. The information above is an educational summary of published receptor biology and does not constitute medical advice.
Related compounds in Metabolic — GLP & Amylin
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